Introduction: On one hand the prevalence of Irritable Bowel Syndrome (IBS) ranges from 4 to 12 percent in the community; on the other hand, Celiac Disease is prevalent in 4% of the IBS patients. Regarding the fact that cereals containing gluten are routinely used in Iran, diagnosing celiac Disease in IBS patients is important for conducting the treatments. The objective of this study was to assess the frequency of Celiac in IBS patients.Materials and Methods: This study was designed as a case control prospective study. Eighty six subjects were enrolled in this study according to Rome II Criteria. The control group included healthy subjects that were checked up on a routine base. The evaluation of Celiac was done through serology exams such as Anti Gliadin and Anti Transglutaminase (IgG and IgA).Results: Thirty eight male and 48 female patients suffering from IBS with a mean age of 34±11.7 years were enrolled in this study. The case and control groups were not significantly different in terms of sex and age. Flatulence, excessive gas passing and mucus passage were the most frequent symptoms in IBS patients. Night symptoms and weight loss (alarm signs) were observed in 37% and 32%, respectively. Elevated Antigliadin Titer was evident in 22 subjects (25%) which suggests a significantly higher rate for the case group as compared to the control group (t=4.67, P=0.0001).Elevated IgG Anti Transglutaminase Titer was observed in 2 cases (2.3%) while IgA Anti Transglutaminase was not elevated in any of the IBS subjects, neither in the control group nor in the case group.Conclusion: Biopsy of small intestine can be suggested to rule out the elevated Antigliadin Titer Celiac Disease in IBS patients.

Up to now, no complete study was carried out about the prevalence and location of periapical granuloma and radicular cysts from the point of view of clinical symptoms (e.g. pain and swelling fistula) in Iran. The data was collected from the files available in the Department of Pathology, faculty of Dentistry, Tehran University of Medical Sciences. With a consideration on different therapeutic methods, a proper method was selected. Radicular cyst occurred in 59.3 percent of 324 cases while 45.7 percent were granuloma. The most common incidence of these lesions was in the range of 24-25 years old. The most common location of lesions was the maxillary anterior. Sinus tracts occurred in 74 of all cases. 47.3 percent of these patients have been previously received root canal therapy. It is noticeable that 24 percent of all patients were treated endodontically before surgery. Higher incidence of granuloma occurred in small lesions while cysts were more common in large lesions. 232 of all cases showed one of the clinical symptoms, 16% pain, 35.8% swelling and 22.8% fistula. No symptoms were found in 92 cases.

Introduction. This fascinating disorder is also known as Sinus Histiocytosis. It is very rare, probably less than 1000 cases reported in the literature. R.D.D affects lymph nodes, although extranodal involvement has been reported such as: Centaral nervous system (CN.S). All of the cases of R.D.D with CN.S involvement without other sites involvement are 11 cases. Methods. The case is a male patient, 26y/o, with a history of head trauma 2 years ago that has been resulted to unconsciousness. He has been referred to a hospital and brain CT scan and brain M.R.I has been done for him. In M.R.I a brain tumor with left orbit and sphenoidal sinus involvement and compression effect on frontal lobe has been seen. A neurosurgeon operated him and the pathological report was Rosai-Dorfman Disease. Then he was referred to radiation therapy department.Results. Treatment approach in CN.S involvement cases consists of surgery, radiotherapy and chemotherapy. Discussion. Over all, response has been inferior to those expected with malignant hematopoietic neoplasms.

Background and Aims: Exercise, as a practical strategy, plays a crucial role in increasing sirtuin 1 protein levels, improving lipid profiles, and preventing complications of overweight and obesity. Therefore, the present study aimed to investigate the effects of exercise training on sirtuin 1 protein levels and lipid profiles in adults with and without Chronic Diseases. Materials and Methods: In the present meta-analysis research, a systematic search of English and Persian studies published in PubMed, Web of Science, Scopus, SID, and Magiran databases was conducted until September 2024. Weighted mean difference and 95% confidence interval (CI) were calculated using random effect model. Heterogeneity was evaluated using the (I2) test, and publication bias was evaluated by visual analysis of the funnel plot and Egger's test. Results: A total of 13 studies (with 15 interventions) and 398 adults with and without Chronic Diseases were meta-analyzed. The results showed that exercise training significantly increased sirtuin 1 [WMD=1.479 (1.103 to 1.856) P=0.001] and high density lipoprotein [WMD=-9.884 (5.166 to 14.603) P=0.001], compared to the control group. However, exercise training significantly decreased total Cholesterol [WMD=-14.071 (-20.057 to -8.085), P=0.001], triglyceride [WMD=-19.616 (-24.058 to -15.175), P=0.001], and low density lipoprotein [WMD=-15.636 (-21.911 to -9.361), P=0.001], compared to the control group in adults with and without Chronic Diseases. Conclusion: The results of the present meta-analysis showed that exercise has a positive effect on sirtuin 1 levels and lipid profile indices in adults with and without Chronic Diseases.